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Treatment of type 2 diabetes mellitus (non-insulin-dependent diabetes), particularly in overweight patients, when dietary management and exercise alone does not result in adequate glycemic control: in adults, metformin (Glucophage) may be used as monotherapy or in combination with other oral antidiabetic agents, or with insulin; in children from 10 years of age and adolescents, metformin (Glucophage) may be used as monotherapy or in combination with insulin.
Intensive glucose control with metformin as first-line therapy in overweight type 2 diabetic adult patients has been shown to reduce diabetes complications.
Prevention of type 2 diabetes mellitus in patients with prediabetes and at least one additional risk factor in whom lifestyle modifications alone have not reached adequate glycemic control.
